MTHFR gene polymorphisms and bladder cancer susceptibility: a meta-analysis including race, smoking status and tumour stage.
Identifieur interne : 000148 ( Main/Exploration ); précédent : 000147; suivant : 000149MTHFR gene polymorphisms and bladder cancer susceptibility: a meta-analysis including race, smoking status and tumour stage.
Auteurs : Soumaya Kouidhi [Tunisie] ; Kamel Rouissi ; Sami Khedhiri ; Slah Ouerhani ; Mohamed Cherif ; Amel Benammar-ElgaaiedSource :
- Asian Pacific journal of cancer prevention : APJCP [ 2476-762X ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Facteurs de risque (MeSH), Fumer (effets indésirables), Génotype (MeSH), Humains (MeSH), Jeune adulte (MeSH), Methylenetetrahydrofolate reductase (NADPH2) (génétique), Polymorphisme génétique (MeSH), Populations d'origine continentale (MeSH), Prédisposition génétique à une maladie (MeSH), Stadification tumorale (MeSH), Sujet âgé (MeSH), Tumeurs de la vessie urinaire (anatomopathologie), Tumeurs de la vessie urinaire (enzymologie), Tumeurs de la vessie urinaire (ethnologie), Tumeurs de la vessie urinaire (génétique), Études cas-témoins (MeSH).
- MESH :
- anatomopathologie : Tumeurs de la vessie urinaire.
- effets indésirables : Fumer.
- enzymologie : Tumeurs de la vessie urinaire.
- ethnologie : Tumeurs de la vessie urinaire.
- génétique : Methylenetetrahydrofolate reductase (NADPH2), Tumeurs de la vessie urinaire.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de risque, Génotype, Humains, Jeune adulte, Polymorphisme génétique, Populations d'origine continentale, Prédisposition génétique à une maladie, Stadification tumorale, Sujet âgé, Études cas-témoins.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Case-Control Studies (MeSH), Continental Population Groups (MeSH), Genetic Predisposition to Disease (MeSH), Genotype (MeSH), Humans (MeSH), Methylenetetrahydrofolate Reductase (NADPH2) (genetics), Middle Aged (MeSH), Neoplasm Staging (MeSH), Polymorphism, Genetic (MeSH), Risk Factors (MeSH), Smoking (adverse effects), Urinary Bladder Neoplasms (enzymology), Urinary Bladder Neoplasms (ethnology), Urinary Bladder Neoplasms (genetics), Urinary Bladder Neoplasms (pathology), Young Adult (MeSH).
- MESH :
- chemical , genetics : Methylenetetrahydrofolate Reductase (NADPH2).
- adverse effects : Smoking.
- enzymology : Urinary Bladder Neoplasms.
- ethnology : Urinary Bladder Neoplasms.
- genetics : Urinary Bladder Neoplasms.
- pathology : Urinary Bladder Neoplasms.
- Adolescent, Adult, Aged, Case-Control Studies, Continental Population Groups, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged, Neoplasm Staging, Polymorphism, Genetic, Risk Factors, Young Adult.
Abstract
Epidemiological studies have investigated that functional polymorphisms in the methylene-tetrahydrofolate reductase (MTHFR) gene may play an essential role in bladder carcinogenesis, but the numerous published studies have reported inconclusive results. The objective of the current study was to conduct an updated analysis in order to investigate the association between polymorphisms in the MTHFR gene and risk of bladder cancer. We searched the Pubmed database for all articles published up to March 31, 2011 that addressed bladder cancer and polymorphisms and variants or mutations of MTHFR for analysis using statistical software. Results for two polymorphisms (C677T and A1298C) in 27 case-control were studies from 15 articles indicated individuals carrying the 677T allele (TC or TT+TC) to have a reduction to a 29% or 21% compared to the wild genotype (CC) in mixed populations (OR: 0.71, 95%CI: 0.55-0.93 or OR: 0.79, 95%CI: 0.64-0.97, respectively) and it is shown that there is significant positive associations between A1298C polymorphism and bladder cancer in Africans (OR: 1.24, 95%CI: 1.02-1.52 for C vs.A; OR: 1.35, 95%CI: 1.10-1.66 for CA vs. AA; OR: 1.29, 95%CI: 1.08-1.55 for CC+CA vs. AA). However, no significant relationship was found in two polymorphisms in the stratified analysis by smoking status. Interestingly, individuals carrying the 677T allele (TT+TC) demonstrated a higher percentage of invasive than superficial cases (OR: 1.38, 95%CI: 1.13-1.69). The results from the current update analysis suggest that C677T and A1298C polymorphisms in the MTHFR gene are associated with bladder cancer risk and prognosis. Further evaluation based on more studies with larger groups of patients are now required.
PubMed: 22296361
Affiliations:
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Le document en format XML
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Reductase (NADPH2)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la vessie urinaire</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Fumer</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Tumeurs de la vessie urinaire</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Tumeurs de la vessie urinaire</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Methylenetetrahydrofolate reductase (NADPH2)</term><term>Tumeurs de la vessie urinaire</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Continental Population Groups</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Polymorphism, Genetic</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Polymorphisme génétique</term><term>Populations d'origine continentale</term><term>Prédisposition génétique à une maladie</term><term>Stadification tumorale</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological studies have investigated that functional polymorphisms in the methylene-tetrahydrofolate reductase (MTHFR) gene may play an essential role in bladder carcinogenesis, but the numerous published studies have reported inconclusive results. The objective of the current study was to conduct an updated analysis in order to investigate the association between polymorphisms in the MTHFR gene and risk of bladder cancer. We searched the Pubmed database for all articles published up to March 31, 2011 that addressed bladder cancer and polymorphisms and variants or mutations of MTHFR for analysis using statistical software. Results for two polymorphisms (C677T and A1298C) in 27 case-control were studies from 15 articles indicated individuals carrying the 677T allele (TC or TT+TC) to have a reduction to a 29% or 21% compared to the wild genotype (CC) in mixed populations (OR: 0.71, 95%CI: 0.55-0.93 or OR: 0.79, 95%CI: 0.64-0.97, respectively) and it is shown that there is significant positive associations between A1298C polymorphism and bladder cancer in Africans (OR: 1.24, 95%CI: 1.02-1.52 for C vs.A; OR: 1.35, 95%CI: 1.10-1.66 for CA vs. AA; OR: 1.29, 95%CI: 1.08-1.55 for CC+CA vs. AA). However, no significant relationship was found in two polymorphisms in the stratified analysis by smoking status. Interestingly, individuals carrying the 677T allele (TT+TC) demonstrated a higher percentage of invasive than superficial cases (OR: 1.38, 95%CI: 1.13-1.69). The results from the current update analysis suggest that C677T and A1298C polymorphisms in the MTHFR gene are associated with bladder cancer risk and prognosis. Further evaluation based on more studies with larger groups of patients are now required.</div></front></TEI><affiliations><list><country><li>Tunisie</li></country><region><li>Gouvernorat de Tunis</li></region><settlement><li>Tunis</li></settlement></list><tree><noCountry><name sortKey="Benammar Elgaaied, Amel" sort="Benammar Elgaaied, Amel" uniqKey="Benammar Elgaaied A" first="Amel" last="Benammar-Elgaaied">Amel Benammar-Elgaaied</name><name sortKey="Cherif, Mohamed" sort="Cherif, Mohamed" uniqKey="Cherif M" first="Mohamed" last="Cherif">Mohamed Cherif</name><name sortKey="Khedhiri, Sami" sort="Khedhiri, Sami" uniqKey="Khedhiri S" first="Sami" last="Khedhiri">Sami Khedhiri</name><name sortKey="Ouerhani, Slah" sort="Ouerhani, Slah" uniqKey="Ouerhani S" first="Slah" last="Ouerhani">Slah Ouerhani</name><name sortKey="Rouissi, Kamel" sort="Rouissi, Kamel" uniqKey="Rouissi K" first="Kamel" last="Rouissi">Kamel Rouissi</name></noCountry><country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Kouidhi, Soumaya" sort="Kouidhi, Soumaya" uniqKey="Kouidhi S" first="Soumaya" last="Kouidhi">Soumaya Kouidhi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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